Dyberg, Cecilia; Fransson, Susanne; Andonova, Teodora; Sveinbjørnsson, Baldur; Lannerholm-Palm, Jessika; Olsen, Thale Kristin; Forsberg, David; Herlenius, Eric; Martinsson, Tommy; Brodin, Bertha; Kogner, Per; Johnsen, John Inge; Wickström, Malin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-24)
Neuroblastoma is a peripheral neural system tumor that originates
from the neural crest and is the most common and deadly tumor of
infancy. Here we show that neuroblastoma harbors frequent
mutations of genes controlling the Rac/Rho signaling cascade
important for proper migration and differentiation of neural crest
cells during neuritogenesis. RhoA is activated in tumors from
neuroblastoma ...